Secretase complexes let it RIP

Winter pressures. Let it flow, let it flow, let it flow.

Neurons let it slide

During mammalian brain development, many neurons migrate away from the site where they are born to settle in distant locations where they send out dendrites and axons to connect with other neurons. Both neuronal migration and axon/dendrite extension depend on forces generated by microtubule-based motor proteins such as cytoplasmic dynein. The effects of these forces depend, however, on the orga...

Identification of Distinct -Secretase Complexes with Different

The -secretase complex catalyzes the final intramembraneous cleavage of the -amyloid precursor protein, liberating the neurotoxic amyloid -peptide implicated in Alzheimer’s disease. Apart from the catalytic subunit presenilin (PS), three additional subunits, nicastrin, APH-1, and PEN-2, have been identified. In mammals, two PS homologues, PS1 and PS2, which are part of distinct -secretase compl...

Let it snow! Let it snow! Let it snow! Estimating cocaine production using a novel dataset based on reported seizures of laboratories

Background: data on cocaine market appear to be inconsistent, as they tend to show declining prices vis a vis a steady or increasing demand and a declining supply. This paper proposes an explanation by providing evidence of an under-estimation of the supply of cocaine. Methods: we put forwa d a conservative estimate of cocaine production in Colombia for year 2008 by means of reported seizures o...

Let it snow! Let it snow! Let it snow! Estimating cocaine production using a novel dataset based on reported seizures of laboratories in Colombia.

BACKGROUND Data on the cocaine market appear inconsistent, as they tend to show declining prices vis-a-vis steady or increasing demand and a declining supply. This paper proposes an explanation for this trend by providing evidence of an under-estimation of the supply of cocaine. METHODS We propose a conservative estimate of cocaine production in Colombia for 2008, using data based on all repo...